The first Vice President of the United States to resign his office occurred on December 28, 1832, when the seventh, John C. Calhoun — serving at the job since March 4, 1825, under two presidents, John Quincy Adams and Andrew Jackson — vacated the position to take up his new calling as Senator from South Carolina (December 29, 1832 – March 3, 1843). After an unsuccessful bid for the presidency and a short stint as Secretary of State, Calhoun returned to the Senate on November 26, 1845, dying in office on March 31, 1850.
On the same date three years later, the great leader Osceola led his Seminole warriors into the Second Seminole War against the United States Army. Eleven years after that, Iowa joined the union as the 29th state.